The authors introduce in this paper the notion of noncommutative Serre fibration (shortly, NCSF) and show that up to homotopy, every morphism between NCCW-complexes is some noncommutative Serre fibration. the authors then associate a six-term exact sequence with the periodic cyclic homology and for K-theory of an arbitrary noncommutative Serre fibration. the authors also show how to use this technique to compute K -groups and cyclic theory groups of some noncommutative quotients. This paper is a follow-up of ideas in Diep (K- Theory Archiv 153,2007, Vietnam 1. Math. 38:363-371, 2010).