Glomerular Filtration of Creatinine: Validation of a Novel Index of Muscle Mass Among Older Adults.

• Tác giả: Juhi Chaudhari, Erin P Flanagin, Vilmundur G Gudnason, Olafur S Indridason, Lesley A Inker, Andrew S Levey, Tatsufumi Oka, Runolfur Palsson, Kristin Siggeirsdottir, Hocine Tighiouart
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : American journal of kidney diseases : the official journal of the National Kidney Foundation , 2025
• Bộ sưu tập: NCBI
• ID: 496133

Tóm tắt

RATIONALE & OBJECTIVE: Low muscle mass is common among older adults and associated with poor prognosis. Quantifying muscle mass is challenging in routine clinical practice. We hypothesized that glomerular filtration of creatinine (GF STUDY DESIGN: Cross-sectional analysis of a community-based prospective cohort. SETTING & PARTICIPANTS: A total of 794 older adults with measured glomerular filtration rate (mGFR) and TTMLA in the AGES-Reykjavik Study. EXPOSURE: Measured GF OUTCOME: TTMLA measured using computed tomography. ANALYTICAL APPROACH: Sex-specific Pearson's correlation and linear regression analyses using continuous and categorical mGF RESULTS: The mean age and mGFR were 80.3±4.0 (SD) years and 62.3±16.5 (SD) mL/min/1.73m LIMITATIONS: Residual confounding by measured and unmeasured variables. CONCLUSIONS: These findings support the validity of GF PLAIN-LANGUAGE SUMMARY: Low muscle mass is common among older adults and is associated with poor clinical outcomes. Quantifying muscle mass is challenging in routine clinical practice. We evaluated whether glomerular filtration of creatinine (GF