OBJECTIVE: It is important to cover energy targets among patients with head and neck cancer (HNC) to minimize weight and skeletal muscles loss. This study aimed to assess the agreement between indirect calorimetry (IC) and predictive equations for determining resting energy expenditures (REE) in HNC patients receiving home enteral nutrition (HEN). RESEARCH METHODS AND PROCEDURES: Patients included in the study had to be diagnosed with HNC, be adults, have artificial access to the digestive tract, and participate in HEN. All measurements were conducted in the morning after prior patient preparation. Body weight and height were measured using a scale with an integrated height meter. A phase-sensitive, single-frequency bioimpedance analyzer was utilized to conduct bioelectrical impedance analysis. REE was measured using IC with a canopy hood and calculated using 27 different equations. Differences between variables were analyzed using appropriate t-tests and their nonparametric counterparts. The Bland-Altman test was used to assess the types of differences between measured REE (mREE) and predicted REE (pREE). RESULTS: The examined patients (n = 71, 73.2% male) had a mean age of 63.99 ± 11.42 years and a BMI of 22.84 ± 3.59 kg/m CONCLUSION(S): The predictive equations examined in this study cannot replace IC for determining REE in HNC patients at the individual level. When equations are used, special attention should be given to planning HEN to account for possible discrepancies between pREE and mREE.