Global warming is seriously threatening sheep farmings by increasing health problems and decreasing reproductive efficiency. In this study, pomegranate peels ethanolic extract (Ppee), rich in phenolic acids, was prepared in free (Fppee) and nanoemulsified (Nppee, with 18.49 nm-21.8 nm particles size) forms. The protective role of the extracts against heat stress impacts on homeothermy, metabolism and redox status, and reproductive performance of ewes was studied. A total of 36 Barki ewes were synchronized to estrus using two intramuscular injections PGF