Right Ventricular Function and Outcomes Stratified by the Effective Regurgitant Orifice Area in Secondary Tricuspid Regurgitation.

• Tác giả: Luigi P Badano, Claudia Baratto, Giorgia Benzoni, Sergio Caravita, Alexandra Clement, Samantha Fisicaro, Oliverio Giorgio, Diana R Hădăreanu, Francesca Heilbron, Denisa Muraru, Gianfranco Parati, Marco Penso, Noela Radu, Antonio Sorropago, Paolo Springhetti, Michele Tomaselli
• Ngôn ngữ: eng
• Ký hiệu phân loại: 370.112 Humanistic education (Liberal education)
• Thông tin xuất bản: England : The Canadian journal of cardiology , 2025
• Bộ sưu tập: NCBI
• ID: 496528

Tóm tắt

 BACKGROUND: In patients with moderate and severe secondary tricuspid regurgitation (STR), the effective regurgitant orifice area (EROA), corrected using the proximal isovelocity surface area (PISA) method for tricuspid valve leaflet tethering and low TR jet velocities, has an unclear threshold for identifying high-risk patients. In this study we aimed to establish a risk-based EROA cutoff and assess the impact of right ventricular (RV) remodeling on outcomes in low-risk patients with STR according to EROA. METHODS: We included 513 consecutive outpatients (age 75 ± 13 years of age, 47% male) with moderate and severe STR. Patients were categorized by spline-derived EROA threshold into low-risk (≤ 0.47 cm RESULTS: Over a follow-up period of 18 ± 15 months, 195 patients reached the composite endpoint. Kaplan-Meier analysis showed a significantly higher event rate in high-risk patients (54 ± 6% vs 30 ± 7%, P <
  0.0001). An EROA >
  0.47 cm CONCLUSIONS: EROA independently predicts outcomes in STR. For low-risk patients by EROA, evaluating RV function and RV-pulmonary artery coupling enhances risk stratification.