Peptide-based PET/CT imaging visualizes PD-L1-driven radioresistance in glioblastoma.

• Tác giả: Man Hu, Yang Li, Zhiguo Liu, Jiazhong Ren, Jian Shi, Jinping Wang, Kelin Wang, Shijie Wang, Yong Wang, Chunhui Yuan, Miaoqing Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 372.427 School-based programs
• Thông tin xuất bản: Scotland : Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy , 2025
• Bộ sưu tập: NCBI
• ID: 496553

Tóm tắt

Radioresistance remains a great challenge for radiotherapy in the treatment of glioblastoma (GBM). PD-L1 expression is a key contributor to radioresistance and immune escape in GBM. The lack of effective methods to monitor the change of PD-L1 during radiotherapy in patients limits timely intervention and management of the resistance. Here, we developed a novel peptide tracer [