Organoid models of drug resistant gastric adenosquamous carcinoma: Recapitulating tumor features and refining precision treatment.

• Tác giả: Wei Chen, Shuying Fu, Tianshun Gao, Tengfei Hao, Yulong He, Jia Li, Kuan Li, Wenchao Li, Chen Wang, Kexin Wang, Yumei Xian, Huan Yang, Leli Zeng, Changhua Zhang, Shiwei Zhang, Jie Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 620.1404 Engineering mechanics and materials
• Thông tin xuất bản: Scotland : Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy , 2025
• Bộ sưu tập: NCBI
• ID: 496756

Tóm tắt

Organoids were successfully established from primary tumor and its metastatic lymph nodes of a patient. These organoids faithfully replicated tumor pathology and genetic characteristics. Organoid-based drug screening was conducted, which revealed significant difference in sensitivity to drugs between organoids dervived from primary tumor versus metastatic lymph nodes. The results guided clinical decisions for personalized treatment for the patient. This approach provides an insightful strategy for advancing treatment for gastric cancer.