Exposure to airborne particulate matter and undernutrition in young rats: An in-depth histopathological and biochemical study on lung and excretory organs.

• Tác giả: Laura Alvarez, Julián Bonetto, Carola Bozal, Fernando Brites, Melisa Kurtz, Christian Lezón, Maximiliano Martin, Ivana Masci, Deborah Tasat
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association , 2025
• Bộ sưu tập: NCBI
• ID: 496776

Tóm tắt

 Environmental stressors, such as air particulate matter (PM) and nutrient deficiencies, can significantly impact crucial organs involved in detoxifying xenobiotics, including lungs, liver, and kidneys, especially in vulnerable populations like children. This study investigated the effect of 4-week exposure to Residual Oil Fly Ash (ROFA) on these organs in young rats under growth-restricted nutrition (NGR). We assessed histological, histomorphometric and biochemical parameters. ROFA exposure induced histological changes and inflammation in all three organs when compared to control (C) animals. Specifically, in lungs ROFA caused a significant reduction in alveolar airspace (C: 55.8 ± 1.8% vs. ROFA: 38.7 ± 3.0%, p <
  0.01) and alveolar number along with changes in alveolar size distribution, and disruption of the smooth muscle layer which may impaired respiratory function. In the liver, ROFA increased binucleated cells, macro and microvesicles and both AST and ALT serum biomarkers (AST: C = 77.7 ± 1.3 vs. ROFA = 81.6 ± 1.3, p <
  0.05
  ALT: C = 44.5 ± 0.9 vs. ROFA = 49.4 ± 1.3, p <
  0.05). In the kidneys, a reduced Bowman's space (C: 2.15 ± 0.2 mm