Selective activation of mesoscale functional circuits via multichannel infrared stimulation of cortical columns in ultra-high-field 7T MRI.

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Tác giả: Meixuan Chen, Yipeng Liu, Anna Wang Roe, Kenneth Edward Schriver, Feiyan Tian

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Cell reports methods , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 497080

 To restore vision in the blind, advances in visual cortical prosthetics (VCPs) have offered high-channel-count electrical interfaces. Here, we design a 100-fiber optical bundle interface apposed to known feature-specific (color, shape, motion, and depth) functional columns that populate the visual cortex in humans, primates, and cats. Based on a non-viral optical stimulation method (INS, infrared neural stimulation
  1,875 nm), it can deliver dynamic patterns of stimulation, is non-penetrating and non-damaging to tissue, and is movable and removable. In addition, its magnetic resonance (MR) compatibility (INS-fMRI) permits systematic mapping of brain-wide circuits. In the MRI, we illustrate (1) the single-point activation of functionally specific networks, (2) shifting cortical networks activated via shifting points of stimulation, and (3) "moving dot" stimulation-evoked activation of higher-order motion-selective areas. We suggest that, by mimicking patterns of columnar activation normally activated by visual stimuli, a columnar VCP opens doors for the planned activation of feature-specific circuits and their associated visual percepts.
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