Molecular Profiling of Odontoclasts during Physiological Tooth Replacement.

• Tác giả: S Flibotte, K Fu, J I Henriquez, J M Richman
• Ngôn ngữ: eng
• Ký hiệu phân loại: 785.13 *Trios
• Thông tin xuất bản: United States : Journal of dental research , 2025
• Bộ sưu tập: NCBI
• ID: 497195

Tóm tắt

The odontoclast is a rarely studied cell type that is overly active in many dental pathologies, leading to tooth loss. It is difficult to find diphyodont mammals in which either physiological or pathological root resorption can be studied. Here we use the adult leopard gecko, which has repeated cycles of physiological tooth resorption and shedding. RNA-seq was carried out to compare gene expression profiles of functional teeth to developing teeth. Genes more highly expressed in bell-stage developing teeth were related to morphogenesis (