Rational design of dual-agonist peptides targeting GLP-1 and NPY2 receptors for regulating glucose homeostasis and body weight with minimal nausea and emesis.

• Tác giả: Yangxin Chen, Jing Han, Neng Jiang, Jing Liu, Yun Liu, Weiwen Lu, Chunli Tang, Weizhong Tang, Shuang Wang, Changhong Wei, Han Wu, Zhiming Yan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: France : European journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 497200

Tóm tắt

There is an urgent need for effective treatments targeting comorbidities of type 2 diabetes (T2DM) and obesity. Developing dual agonists of glucagon-like peptide 1 receptor (GLP-1R) and neuropeptide Y receptor type 2 (NPY2R) with combined PYY