OBJECTIVES: To overcome the shortcomings of sintered bone graft materials, low-crystallinity apatite (LCA) was developed using a non-heated approach to enhance resorption and integration during bone regeneration. This study aimed to evaluate the efficacy of LCA as a synthetic bone graft material for bone reconstruction. METHODS: LCA was compared to three conventional synthetic bone graft materials: biphasic calcium phosphate (BCP) 37, BCP 64, and octacalcium phosphate (OCP). Crystalline structure and surface morphology were examined using X-ray diffraction (XRD) and scanning electron microscopy (SEM). In vivo testing was conducted using a rabbit calvarial augmentation model, in which the grafts were placed into standardized defects. Bone formation and graft resorption were analyzed using micro-computed tomography (micro-CT) and histomorphometric analyses at three and six weeks post-implantation. RESULTS: LCA exhibited structural similarities to the allograft material and enhanced surface properties. Micro-CT and histomorphometric evaluations at three and six weeks post-implantation demonstrated higher rates of bone formation and substantial volumetric changes with LCA, indicating efficient graft resorption and bone regeneration. CONCLUSIONS: LCA exhibited superior integration, osteoconductivity, and biodegradability compared to other synthetic grafts, suggesting the potential for improved clinical outcomes with its use. Although the efficacy of LCA has been validated, further studies in diverse biological environments are necessary to confirm its safety and effectiveness for broader clinical use. CLINICAL SIGNIFICANCE: LCA, which mimics natural bone structure and has superior integration and osteoconductivity, has the potential for clinical applications requiring rapid and effective bone healing.