A review of kappa opioid receptor antagonists and their clinical trial landscape.

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Tác giả: Malliga R Iyer, Maloba M M Lobe, Vaishali M Patil, Saroj Verma

Ngôn ngữ: eng

Ký hiệu phân loại: 363.738492 Environmental problems

Thông tin xuất bản: France : European journal of medicinal chemistry , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 497280

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Myriad signaling pathways are implicated in neuropsychiatric disorders, yet many mechanisms are unknown and current treatment options are limited. The intriguing dynorphin/kappa opioid receptor (KOR) system that is widely distributed throughout the brain appears to be essential in regulating many physiological and pathophysiological processes. This review explores up to date advances on the relationship between the dynorphin/KOR system with a particular focus on the KOR antagonist compounds tested as clinical candidates that could offer potential treatment options for CNS disorders.

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