INTRODUCTION AND IMPORTANCE: Mesenteric panniculitis is a rare, benign condition characterized by chronic inflammation and fibrosis of mesenteric adipose tissue (Hussein and Abdelwahed, 2015
Gögebakan et al., 2018 [1, 2]). While its etiology remains unclear in many cases, it has been associated with various conditions including abdominal surgery, trauma, and inflammatory diseases (Buragina et al., 2019 [3]). Understanding its presentation and management is crucial for proper patient care. CASE PRESENTATION: We present a case of mesenteric panniculitis in a 49-year-old woman who presented with significant weight loss. The diagnosis was confirmed through imaging studies and tissue biopsy, with successful symptomatic management through conservative treatment. CLINICAL DISCUSSION: The condition typically presents with nonspecific symptoms including abdominal pain, nausea, and weight loss, though it may be discovered incidentally. Diagnosis relies on a combination of imaging findings, particularly the characteristic "misty mesentery" appearance on CT scan, and when indicated, histological confirmation. CONCLUSION: Early recognition and appropriate management of mesenteric panniculitis are essential for optimal outcomes. While usually benign, the condition requires thorough evaluation to exclude underlying malignancy and careful monitoring to prevent complications.