Design and preclinical evaluation of

• Tác giả: Lina Diao, Dajie Ding, Junhong Feng, Peiwen Han, Jianyong Jiang, Yuhao Jiang, Zuojie Li, Qing Ruan, Qianna Wang, Guangxing Yin, Junbo Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 519.57 Design of experiments
• Thông tin xuất bản: France : European journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 497466

Tóm tắt

Fibroblast activation protein (FAP) is a crucial target for tumor diagnosis and treatment. FAP inhibitors (FAPIs) can selectively bind to FAP, and ligands with multiple targeting groups are anticipated to improve tumor-specific uptake. A dimeric FAPI ligand (L2) with high affinity for FAP was selected. Four hydrophilic