Discovery of BW710 as a potent, selective and orally bioavailable fibroblast growth factor receptor 2 (FGFR2) inhibitor.

• Tác giả: Shaohua Chang, Ke Ding, Huiqiong Li, Dawei Ma, Yuan Tian, Zhen Wang, Pinglian Wu, Qiuju Xun, Bowen Yang, Yang Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 769.565 *Covers
• Thông tin xuất bản: France : European journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 497470

Tóm tắt

While fibroblast growth factor receptor 2 (FGFR2) emerges as an appealing cancer therapeutic target, so far there is no selective FGFR2 inhibitor on the market. Here, we report the discovery of a series of new selective, irreversible FGFR2 inhibitors with compound BW710 being the representative. Compound BW710 potently inhibited the proliferation of BaF3-FGFR2 cells with an IC