Arterial stenosis, which is the progressive narrowing of the lumen of blood vessels, severely compromises perfusion and leads to complex hemodynamic alterations. Evolving to address this challenge, hybrid nanofluids have emerged as a truly transformative solution due to their superior thermal and fluid properties. The present study numerically investigates the flow and heat transfer phenomena of two hybrid nanofluids, namely Silver-Gold (Ag-Au) and Copper-Titanium dioxide (Cu-TiO