Multi-matrix HPLC investigation of preservatives employing a recent validated method: A Monte Carlo simulation approach to health risks in Bangladeshi processed foods and healthcare.

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Tác giả: Dipankar Chakraborty, Sreebash Chandra Bhattacharjee, Suman Das, Md Ashraful Islam, Md Samrat Mohay Menul Islam, Abu Saleh Mohammad Khaled, Md Nurun Nabi, Mohammad Rafiul Omar Khan Noyon, Mohammad Nasir Uddin, Monir Uddin

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 497480

To determine the amounts of benzoic acid, sorbic acid, methylparaben, and propylparaben in an assortment of products, this study provides a validated HPLC-PDA method. Linearity, recovery, accuracy, precision, sensitivity, specificity, system suitability, and robustness were all examined throughout validation in compliance with ICH criteria. The method of measurement showed high reliability, precision, and linear calibration curves (5-50 mg/L) with correlation values over 0.999, demonstrating that it is suitable for consistent analysis. Reliability across various matrices was validated by robustness testing. Goods such as fruit juices, ketchup, cakes, herbal goods, and pharmaceuticals were subjected to health risk assessments including CDI, THQ, and HI. Significant sorbate and high benzoate levels, in particular in herbal products (up to 6636 mg/kg), were found in processed meals, while methylparaben surpassed the recommended limit in some herbal and pharmaceutical products. Levels of propylparaben remain low. Risk evaluations revealed that consumption of herbal products was the main cause of significant worry, especially for children with lower body weights. THQ levels below the threshold were found in Monte Carlo simulations (5th, median, and 95th percentiles), indicating that food preservatives provide little non-carcinogenic risk to the majority of the population.
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