B7-H3-liquid biopsy for the characterization and monitoring of the dynamic biology of prostate cancer.

• Tác giả: Jie-Fu Chen, Zijing Chen, Lilit Gevorkian, Jun Gong, You-Ren Ji, Yong Ju, Hyoyong Kim, Junseok Lee, Aaron Phung, Edwin M Posadas, Brenda Salumbides, Kevin Scher, Hsian-Rong Tseng, Kai Han Tu, Jasmine J Wang, Joshua Watson, Ying-Tzu Yen, Sungyong You, Ryan Y Zhang, Chen Zhao, Yazhen Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: Scotland : Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy , 2025
• Bộ sưu tập: NCBI
• ID: 497566

Tóm tắt

BACKGROUND: B7-H3 is a promising target for cancer therapy, notably in prostate cancer (PCa), particularly in metastatic, castration-resistant PCa (mCRPC). With the development of B7-H3-targeted therapies, there is a need for a rapid, reliable, and cost-effective method to detect and monitor B7-H3 expression. Leveraging their abundance and stability, we developed a liquid biopsy assay using extracellular vesicles (EVs) for this purpose. METHODS: B7-H3 RESULTS: The assay detected higher B7-H3 CONCLUSIONS: This B7-H3