Nilotinib impairs relaxation and temporal electro-mechanical integrity in human iPS-derived cardiomyocyte sheets.

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Tác giả: Ai Goto, Yukiko Himeno, Hiroko Izumi-Nakaseko, Ryuichi Kambayashi, Yasunari Kanda, Yoshinobu Nagasawa, Atsuhiko T Naito, Ayako Okado-Matsumoto, Yuko Sekino, Atsushi Sugiyama, Yoshinori Takei

Ngôn ngữ: eng

Ký hiệu phân loại: 784.190287 General principles, musical forms, instruments

Thông tin xuất bản: United States : Toxicology and applied pharmacology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 497599

INTRODUCTION: Nilotinib, an anti-tumor tyrosine kinase inhibitor against BCR-ABL1, has been clinically reported to cause QT prolongation, but currently lacks evidence for a risk of torsade de pointes. Indeed, it is poorly understood why nilotinib rarely induces torsade de pointes. METHODS AND RESULTS: We adopted two-dimensional human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) sheets to examine effects of nilotinib on their electrophysiological and mechanical properties besides intracellular calcium (Ca CONCLUSION: Nilotinib could deteriorate relaxation ability and temporal electrical integrity of the heart through impairing Ca
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