Synthesis and evaluation of novel ebselen derivatives as urease inhibitors for combating Helicobacter pylori infections.

• Tác giả: Weilong Cao, Kairui Feng, Dingding Gao, Zongqing Jia, Feng Jin, Shanshan Jin, Fahui Li, Binzhuo Liu, Peng Peng, Weiguo Song, Guangzhao Xu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 378.242 Thesis and dissertation requirements
• Thông tin xuất bản: France : European journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 497644

Tóm tắt

The development of novel inhibitors targeting urease that affects the colonization of Helicobacter pylori (H. pylori) is a promising strategy to address the growing challenge of antibiotic resistance. In this study, a novel urease covalent inhibitor, XBP2 (IC