Anticancer activity promoted by ligand diversity in diiron thiocarbyne complexes.

• Tác giả: Lorenzo Biancalana, Lorenzo Chiaverini, Sanja Jelača, Danijela Maksimović-Ivanić, Fabio Marchetti, Ekatarina Mihajlović, Sanja Mijatović, Marija Mojić, Stefano Zacchini
• Ngôn ngữ: eng
• Ký hiệu phân loại: 940.54779 1918
• Thông tin xuất bản: France : European journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 497727

Tóm tắt

Mononuclear iron (II) complexes have been intensively investigated with the aim of developing efficacious anticancer drugs that can overcome the serious limitations associated with the platinum complexes currently employed in chemotherapy. Combining a promising antitumor potential with appropriate physicochemical properties, such as aqueous stability and a balanced hydrophilic/lipophilic character, is essential for clinical progression. We prepared six highly functionalized diiron(I) complexes from the μ-thiocarbyne precursor [Fe