Fraglide-1 from traditional Chinese aromatic vinegar: A natural AhR antagonist for atopic dermatitis.

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Tác giả: Miki Akamatsu, Saya Kakimaru, Kosuke Kato, Mayuko Koreishi, Masahiro Miyashita, Yoshiyuki Murata, Yoshimasa Nakamura, Ayano Satoh, Masahiro Takagi, Yoshio Tsujino

Ngôn ngữ: eng

Ký hiệu phân loại: 664.55 Vinegar

Thông tin xuất bản: England : Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 497763

Traditional Chinese Zhenjiang aromatic vinegar (Kozu) contains Fraglide-1 (FG1), a bioactive lactone with demonstrated peroxisome proliferator-activated receptor gamma (PPARγ) agonist and antioxidant activities. This study explored FG1's novel ability to antagonize the aryl hydrocarbon receptor (AhR) signaling pathway, which regulates artemin expression and contributes to itching and inflammation in atopic dermatitis. Through molecular docking simulations and cell-based assays in human keratinocytes, we demonstrated FG1's potent antagonistic activity against AhR signaling. FG1 effectively suppressed FICZ-induced inflammatory responses, including artemin expression, with potency (half maximal inhibitory concentration, IC
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