Single or double lipid-modified ultra-short antimicrobial peptides for treating infections caused by resistant bacteria.

• Tác giả: Zufang Ba, Sanhu Gou, Beibei Li, Hui Liu, Xueting Liu, Yao Liu, Jingman Ni, Xu Ouyang, Bingqian Ren, Yu Wang, Qingyang Xu, Pengyi Yan, Tingting Yang, Yuhe Yang, Zhongwei Yu, Liru Yuan, Jingying Zhang, Yun Zhang, Yuhuan Zhao, Chao Zhong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 519.702 Single-stage programming
• Thông tin xuất bản: France : European journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 498150

Tóm tắt

Unmodified ultra-short antimicrobial peptides (AMPs) have difficulty attaining high antimicrobial activity and low toxicity concurrently. Our previous studies have shown that single-site lipid modification can enhance the antimicrobial activity of AMPs. However, research on multi-site modification is scarce. This study designed and synthesized a series of single/double-site lipid-modified ultra-short AMPs. Particularly, the new single-site lipid-modified AMP C12 (C12-KKWW-NH