Ảnh hưởng của cao chiết từ thân cây mớp gai (lasia spinosa) đến hoạt tính của enzyme glucose-6-phosphatase ở gan và thận của chuột bị bệnh đái tháo đường

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Tác giả: Thị Xuân Trang Đái, Nhi Linh Phạm, Lâm Tài Tạ, Chí Linh Trần

Ngôn ngữ: vie

Ký hiệu phân loại: 616.462 Diabetes mellitus

Thông tin xuất bản: Khoa học và Công nghệ - Đại học Thái Nguyên, 2021

Mô tả vật lý: 47-54

Bộ sưu tập: Metadata

ID: 498233

Thêm vào giỏ

Nghiên cứu được thực hiện để đánh giá tác động điều hòa hoạt tính enzyme glucose-6-phosphatase trong gan và thận của cao chiết thân mớp gai trên chuột bị bệnh đái tháo đường do alloxan monohydrate. Trong nghiên cứu này, bệnh đái tháo đường ở chuột đã được gây ra bằng cách tiêm alloxan monohydrate vào trong xoang bụng chuột. Khởi phát bệnh đái tháo đường đã làm tăng hàm lượng glucose huyết và glucose-6-phosphatase một cách đáng kể (p<
0,05). Cao chiết từ thân mớp gai được sử dụng ở liều 100, 200 và 400 mg/kg đối với chuột đái tháo đường do alloxan monohydrate gây ra làm giảm đáng kể (p <
0,05) hàm lượng glucose huyết so với nhóm đái tháo đường. Cao chiết từ thân mớp gai làm giảm hoạt tính của enzyme glucose-6-phosphatase ở gan và thận được phát hiện ở chuột đái tháo đường. Phân tích mô bệnh học của gan và thận cho thấy sự phục hồi khi sử dụng cao chiết thân mớp gai điều trị cho các nhóm chuột đái tháo đường. Cao chiết từ thân mớp gai ở liều lượng cụ thể có tác dụng chống bệnh đái tháo đường thông qua việc điều chỉnh hoạt động của enzyme glucose-6-phosphatase giúp bảo vệ gan và thận. Do đó, cao chiết thực vật này có lợi trong việc điều trị bệnh đái tháo đường.The study was conducted to evaluate the regulatory effects enzyme glucose-6-phosphatase activity in the liver and kidney of Lasia spinosa stem extract on alloxan monohydrate-induced diabetes in mice. In this investigation, diabetes has been induced by intraperitoneal injection of alloxan monohydrate. Induction of diabetes increased the level of blood glucose and enzyme glucose-6-phosphatase significantly (p<
0.05). Administration of Lasia spinosa at 100, 200 and 400 mg/kg body weight doses to alloxan monohydrate induced diabetic mice resulted in a significant decrease (p<
0.05) in blood glucose level of the extract administered groups as compared to the diabetic control group. The Lasia spinosa reduced the enzyme glucose-6-phosphatase activity in the liver, kidney was found to be ameliorated in diabetic mice. Histopathological alternations of the liver, kidney tissues were also found to be restored in Lasia spinosa treated diabetic groups. The results showed that Lasia spinosa stem extract, at specific doses, has an anti-diabetic effect through its regulates enzyme glucose-6-phosphatase activity, protect liver and kidney. Hence, this plant extract may be beneficial in the treatment of diabetes.

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