Đánh giá hiệu quả điều trị của phác đồ 4 thuốc có bismuth tiệt trừ helicobacter pylori ở bệnh nhân viêm loét dạ dày - tá tràng tại bệnh viện trường đại học y dược Cần Thơ năm 2020

Đánh giá hiệu quả điều trị của phác đồ 4 thuốc có bismuth tiệt trừ helicobacter pylori ở bệnh nhân viêm loét dạ dày - tá tràng tại bệnh viện trường đại học y dược Cần Thơ năm 2020 - 2021

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Tác giả: Thái Ngọ Đoàn, Hiếu Tâm Huỳnh

Ngôn ngữ: vie

Ký hiệu phân loại: 615.35 Enzymes

Thông tin xuất bản: Y Dược học Cần Thơ, 2021

Mô tả vật lý: 29-35

Bộ sưu tập: Metadata

ID: 498348

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Helicobacter pylori infection is one of the most common causes of gastritis and peptic ulcer disease. Bismuth-containing quadruple regimen is recommended selection as first- line therapy for patients with Helicobacter pylori infection in areas with high clarithromycin rates resistance. Currently, in the Mekong Delta, there have been microscopic researches on the result of this regimen on Helicobacter pylori infection treatment, especially in Can Tho city. Objectives: To evaluate the treatment effects of the Bismuth-containing quadruple regimen for treating gastritis and peptic ulcer disease of Helicobacter pylori infection. Materials and methods: A cross-sectional descriptive was conducted on 75 patients gastritis and peptic ulcer disease of Helicobacter pylori infection conducted at Internal Medicine Clinic, Can Tho University of Medicine and Pharmacy Hospital from May 2020 to May 2021. All patients have treated Bismuth-containing quadruple regimen (RBMT) for 14 days. From four to eight weeks after the completion of therapy, Helicobacter pylori infection status was rechecked by rapid urease test or C13 urea-breath test. Results: The HP eradication success rate was 94.7%, the failure rate was 5.3%. The rate of successful eradication of HP in groups under 40 years old, 40-59 years old and ≥ 60 years old were 100%, 96.3% and 72.7%, respectively. The difference in HP eradication rate in these three groups was statistically significant (p=0.004). Side effects occurred in 16%. The common side effects were nausea, headache and diarrhea. Conclusion: Bismuth-containing quadruple regimen achieved very high eradication rates. Side effects were uncommon but not severe.Nhiễm vi khuẩn Helicobacter pylori là một trong những nguyên nhân thường gặp nhất gây ra viêm loét dạ dày - tá tràng. Phác đồ 4 thuốc có Bismuth được khuyến cáo chọn lựa đầu tiên cho bệnh nhân nhiễm Helicobacter pylori ở vùng có tỷ lệ đề kháng clarithromycin cao. Hiện tại ở Đồng bằng sông Cửu Long có rất ít nghiên cứu về kết quả của phác đồ này, đặc biệt tại thành phố Cần Thơ. Mục tiêu nghiên cứu: Đánh giá hiệu quả điều trị của phác đồ 4 thuốc có Bismuth trong điều trị viêm loét dạ dày - tá tràng do nhiễm Helicobacter pylori (HP). Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 75 bệnh nhân đến khám tại phòng khám Nội, Bệnh viện Trường Đại học Y Dược Cần Thơ từ 05/2020 đến 05/2021. Bệnh nhân được chẩn đoán viêm loét dạ dày - tá tràng có nhiễm Helicobacter pylori và được điều trị phác đồ 4 thuốc có Bismuth (RBMT) trong 14 ngày. Trong vòng 4-8 tuần sau khi ngưng điều trị, tình trạng còn nhiễm HP được kiểm tra lại bằng urease test nhanh hoặc C13 urea-breath. Kết quả: Tỷ lệ tiệt trừ thành công HP là 94,7%, thất bại là 5,3%. Tỷ lệ tiệt trừ HP thành công ở nhóm dưới 40 tuổi, 40-59 tuổi và ≥ 60 tuổi tương ứng là 100%, 96,3% và 72,7%. Sự khác biệt tỷ lệ tiệt trừ HP ở ba nhóm này có ý nghĩa thống kê (p=0,004).Tác dụng phụ chiếm 16%. Các phản ứng phụ thường gặp buồn nôn, nhức đầu, tiêu chảy. Kết luận: Phác đồ 4 thuốc có Bismuth có tỷ lệ tiệt trừ HP rất cao. Tác dụng phụ ít gặp nhưng không nghiêm trọng.

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