Terpene and lignan glycosides from the leaves of Cyclocarya paliurus and their anti-inflammatory activity.

• Tác giả: Hui-Lin Dong, Si-Yang Fang, Can Hu, Jia Liu, Ke Pan, Yan-Hua Qin, Lei Wang, Chang-Jian Wu, Zhi-Qi Yin, Dong-Jian Zhang, Jian Zhang, Xing-Gui Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Phytochemistry , 2025
• Bộ sưu tập: NCBI
• ID: 498584

Tóm tắt

Nine undescribed glycosides including five terpene glycosides (1-5) and four lignan glycosides (6-9), together with thirteen known compounds, were isolated from the n-BuOH fraction of the leaves of Cyclocarya paliurus. Their structures including absolute configuration were elucidated by extensive spectroscopic analysis and computational methods including NMR and ECD calculations. All isolates were screened for inhibitory effect against LPS-induced nitric oxide production in RAW 264.7 cells. Compound 12 showed the most potent activity with an IC