Nghiên cứu thay đổi hồng cầu, bạch cầu và procalcitonin ở bệnh nhân ung thư phổi nguyên phát tại thời điểm chẩn đoán

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Thùy Linh Đặng, Văn Giao Lê, Đình Hưng Thiều, Thu Hoài Vũ

Ngôn ngữ: vie

Ký hiệu phân loại: 362.19624 Physical illness

Thông tin xuất bản: Tạp chí Y học lâm sàng - Bệnh viện Trung ương Huế, 2022

Mô tả vật lý: 93-99

Bộ sưu tập: Metadata

ID: 498655

Thêm vào giỏ

To determine the change of red blood cell, white blood cell counts and serum procalciton level in patients with primary lung cancerat time of diagnosis. A descriptive, cross - sectional study was conducted at time of diagnosis of 140 lung cancer patients versus 40 pneumonia patients at Oncology Department, 71 Central Hospital, from 7/2017 to 10/2020. Red blood cell (RBC), white blood cell counts (WBC), and serum procalcitonin (PCT) level were evaluated. The mean value of hemoglobin in the lung cancer group was lower than that in the pneumonia group, which was 92.90 ± 27.10g/L compared with 117.78 ± 35.08g/L (p <
0.01). The mean of hemoglobin in the small - cell lung cancer group was lower than that in the non - small - cell lung cancer group, which was 57.77 ± 4.57g/L and 96.50 ± 25.84g/L, respectively (p <
0.01). The WBC in the lung cancer group was 12.07 ± 4.53G/L, higher than in the pneumonia group of 8.52 ± 4.16G/L (p <
0.01). The histopathological group had an average WBC of 15.23 ± 1.42G/L in the non - small - cell lung cancer group, compared to 11.74 ± 4.62G/L in the small - cell lung cancer group (p <
0.01). Stage IV non - small - cell lung cancer and extensive - stage small cell lung cancer had the highest WBC of 15.44 ± 1.99 and 15.56 ± 1.42G/L. PCT within 0.05 and 2ng/ml in the lung cancer group and the pneumonia group was 0.81 ± 0.97ng/ml and 0.88 ± 0.84ng/ml, respectively
but PCT >
10ng/ml in the pneumonia group was higher than that in the lung cancer group, which was 13.13 ± 2.49ng/ml and 12.05 ± 1.64ng/ml. PCT in 3 levels between the lung cancer group and the pneumonia group did not differ. This study showed a difference in hemoglobin in the lung cancer group was lower than the pneumonia group. The WBC in the lung cancer group was higher than the pneumonia group. The rate of anemia was more common in the group of patients with advanced cancer. PCT >
10ng/ml concentration of the pneumonia group was higher than the lung cancer groupXác định sự thay đổi chỉ số hồng cầu, bạch cầu, procalcitonin trên bệnh nhân ung thư phổi nguyên phát tại thời điểm chẩn đoán. Phương pháp: Nghiên cứu mô tả cắt ngang tại thời điểm chẩn đoán ban đầu của 140 bệnh nhân ung thư phổi so với 40 bệnh nhân viêm phổi về hồng cầu, bạch cầu máu ngoại vi và procalcitonin tại khoa ung bướu bệnh viện 71 Trung Ương thời gian tháng 7/2017 đến 10/2020. Kết quả: Giá trị trung bình lượng huyết sắc tố nhóm ung thư phổi thấp hơn nhóm viêm phổi là 92,90 ± 27,10g/L so với 117,78 ± 35,08g/L p <
0,01. Lượng huyết sắc tố trung bình nhóm ung thư phổi tế bào nhỏ thấp hơn ung thư phổi không tế bào nhỏ là 57,77 ± 4,57g/L so với 96,50 ± 25,84g/L với p <
0,01. Số lượng bạch cầu nhóm ung thư phổi 12,07 ± 4,53G/L cao hơn nhóm viêm phổi 8,52 ± 4,16G/L có ý nghĩa thống kê p <
0,01. Theo mô bệnh học có số lượng bạch cầu trung bình của nhóm ung thư phổi tế bào nhỏ cao hơn ung thư phổi không tế bào nhỏ là 15,23 ± 1,42G/L so với 11,74 ± 4,62G/L sự khác biệt p <
0,01. Ung thư phổi không tế bào nhỏ giai đoạn IV và ung thư phổi tế bào nhỏ giai đoạn lan rộng có số lượng trung bình bạch cầu cao nhất là 15,44 ± 1,99G/L và 15,56 ± 1,42G/L. Nồng độ procalcitonin 0,05 <
Procalcitonin <
2ng/ ml của ung thư phổi và nhóm viêm phổi lần lượt 0,81 ± 0,97ng/ml và 0,88 ± 0,84ng/ml nhưng procalcitonin >
10ng/ml nhóm viêm phổi cao hơn nhóm ung thư phổi 13,13 ± 2,49ng/ml so với 12,05 ± 1,64ng/ml. Nồng độ procalcitonin ở 3 mức độ giữa nhóm ung thư phổi so với viêm phổi không khác biệt với p >
0,05. Kết luận: Nghiên cứu này chỉ ra rằng có sự khác biệt về lượng huyết sắc tố nhóm ung thư phổi thấp hơn nhóm viêm phổi. Tỷ lệ thiếu máu gặp nhiều ở nhóm bệnh nhân ung thư giai đoạn muộn. Số lượng bạch cầu nhóm ung thư phổi cao hơn nhóm viêm phổi. Nồng độ procalcitonin >
10ng/ml nhóm viêm phổi cao hơn nhóm ung thư phổi.

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