Xác định hoạt chất dexamethason bẳng phương pháp sắc ký lỏng cao áp (HPLC) có trong mỹ phẩm lưu hành trên địa bàn thành phố Vinh năm 2021

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Tác giả: Thị Soa Đặng, Thị Dung Hồ, Thị Thủy Vũ

Ngôn ngữ: vie

Ký hiệu phân loại: 668.5 Perfumes and cosmetics

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2022

Mô tả vật lý: 131-135

Bộ sưu tập: Metadata

ID: 498758

Thêm vào giỏ

Một số nhà sản xuất bất chấp sự an toàn của người tiêu dùng đã trộn một số thuốc vào trong mỹ phẩm, đặc biệt là các chất thuộc nhóm Glucocorticoid. Các mỹ phẩm trộn Glucocorticoid có nhiều tác dụng phụ không mong muốn như: teo da, xơ cứng bì, viêm da đỏ ửng, giãn mao mạch, mụn trứng cá hoặc bội nhiễm nấm, vi khuẩn và virus, chậm liền sẹo, đục thủy tinh thể hoặc tăng nhãn áp[1].Từ thực tiễn nêu trên, chúng tôi thực hiện với mục tiêu sau: Định tính, định lượng dexamethason trong một số mỹ phẩm lưu hành trên tại địa bàn Thành phố Vinh. Đối tượng và phương pháp nghiên cứu. 10 mẫu mỹ phẩm thu thập trên địa bàn Thành phố Vinh năm 2021. Tiến hành xác định Corticoid bằng phương pháp của Viện Kiểm nghiệm thuốc Trung Ương 2010. Kết quả. Qua khảo sát các điều kiện tối ưu của phương pháp như : Độ đặc hiệu, khoảng tuyến tính, độ lặp lại, độ tái lặp, hiệu suất thu hồi chúng tôiđánh giá phương pháp nghiên cứu hoàn toàn phù hợp để áp dụng vào phân tích các mẫu mỹ phẩm. 10 mẫu phân tích thì có 01 mẫu (MP- 08) có chứa chất dexamethason photphat có thời gian lưu (3'033'') tương đương với thời gian lưu của mẫu chuẩn (3'087''), với nồng độ xác định được là 147mg/g. Còn 09 mẫu còn lại không chứa chất dexamethason photphat. Kết luận. Kết quả này ít nhiều cho thấy còn có chất Corticoid trong mỹ phẩm, nguy cơ tiềm ẩn với sức khỏe người sử dụng từ các mặt hàng mỹ phẩm đang lưu hành trên thị trường.Some manufacturers, despite the safety of consumers, have mixed some drugs into cosmetics, especially those of the Glucocorticoid group. Glucocorticoid mixed cosmetics have many undesirable side effects such as: skin atrophy, scleroderma, erythematous dermatitis, capillary dilation, acne or superinfection of fungi, bacteria and viruses, slow healing of scars, cataracts crystals or glaucoma[1]. From the above practice, we carry out with the following objectives: Qualitative and quantitative dexamethasone in some cosmetics circulating in Vinh City. Research subjects and methods. 10 cosmetic samples collected in Vinh City in 2021. Determined Corticoid by method of Central Institute for Drug Testing 2010. Results. Through surveying the optimal conditions of the method such as specificity, linearity, repeatability, reproducibility, and recovery efficiency, we evaluate that the research method is completely suitable for application in the analysis. cosmetic samples. Of 10 analyzed samples, one sample (MP-08) contained Dexamethasone phosphate with a retention time (3'033'') equivalent to that of the standard sample (3'087''), with a precise concentration determined to be 147 mg/g. The remaining 9 samples did not contain dexamethasone phosphate. Conclusion. This result more or less shows that there are still corticosteroids in cosmetics, potential risks to users' health from cosmetic products circulating on the market.

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