Nghiên cứu đặc điểm lâm sàng và nồng độ procalcitonin huyết thanh trong nhiễm trùng sơ sinh giai đoạn sơ sinh sớm tại Bệnh viện Đa khoa tỉnh Ninh Thuận

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Tác giả: Huy Thạch Lê, Quốc Thắng Lê, Văn Thanh Lê, Thị Thùy Linh Trương

Ngôn ngữ: vie

Ký hiệu phân loại: 616.94 *Bacterial blood diseases

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2022

Mô tả vật lý: 226-231

Bộ sưu tập: Metadata

ID: 498764

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Neonatal infection early period is one of the most common causes of neonatal deaths globally. Objective: Describe clinical and serum procalcitonin concentration in early period neonatal infections. Subjects and Methods: Longitudinal study on 39 infants from 1 to 7 days old, treated for neonatal infections at pediatrics department, Ninh Thuan province general hospital, from January to september 2021. Results: Clinical: Systemic: Pale yellow skin (12.8%), fever (12.8%), cyanosis (12.8%). The cardiac: heart rate ≥160 beats/minute (15.4%), CRT >
3 seconds (7.7%). Respiratory: breathing rate ≥60 beats/minute (33.3%) and <
20 beats/minute (12.8%), breathlessness (10.3%), apnoea (7.7%). Neurological: decreased reflexes (51.3%), poor muscle tone (30.8%), inflexibility (20.5%). Gastrointestinal: poor feeding/ give up sucking (38.5%), vomiting (30.8%), abdominal distention (12.8%). Median serum PCT concentration in the neonatal infection early period group (4.3 ng/ml) was higher than that in the uninfected group (p<
0.05). The area under the curve was 0.96 (p<
0.001) high or low PCT concentrations were able to identify neonatal infection early period with a cut-off 0.17 ng/ml with a sensitivity of 97% and a specificity of 86%. Conclusion: The degree of clinical manifestations is highly variable and PCT is very valuable in the diagnosis of neonatal infection early period.Nhiễm trùng sơ sinh giai đoạn sơ sinh sớm (NTSSS) là một trong những nguyên nhân phổ biến nhất gây tử vong sơ sinh trên toàn cầu. Mục tiêu: Mô tả lâm sàng và nồng độ procalcitonin huyết thanh trong nhiễm trùng sơ sinh giai đoạn sơ sinh sớm. Đối tượng và Phương pháp: Nghiên cứu theo dõi dọc trên 39 trẻ sơ sinh từ 1-7 ngày tuổi, được điều trị nhiễm trùng sơ sinh tại khoa Nhi, Bệnh viện Đa khoa tỉnh Ninh Thuận từ tháng 1 đến tháng 9 năm 2021. Kết quả: Lâm sàng: Toàn thân: da vàng tái (12,8%), sốt (12,8%), nổi vân tím (12,8%). Tim mạch: tần số tim ≥160 lần/phút (15,4%), CRT >
3 giây (7,7%). Hô hấp: nhịp thở ≥60 lần/ phút (33,3%) và <
20 lần/phút (12,8%), dấu gắng sức (10,3%), cơn ngưng thở (7,7%). Thần kinh: giảm phản xạ (51,3%), trương lực cơ giảm (30,8%), kém linh hoạt (20,5%). Tiêu hóa: bú kém/ bỏ bú (38,5%), nôn (30,8%), chướng bụng (12,8%). Trung vị nồng độ PCT huyết thanh nhóm NTSSS (4,3 ng/ml) cao hơn so với nhóm không NTSSS (p<
0,05). Diện tích dưới đường cong 0,96 (p<
0,001) nồng độ PCT cao hoặc thấp có khả năng xác định được NTSSS với điểm cắt 0,17 ng/ml thì độ nhạy 97% và độ đặc hiệu 86%. Kết luận: Lâm sàng của NTSSS đa dạng và PCT có giá trị rất tốt trong chẩn đoán NTSSS.

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