Mối liên quan giữa kiểu hình miễn dịch CD44, ALDH với đặc điểm nội soi và mô bệnh học trong ung thư biểu mô tuyến dạ dày

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Tác giả: Thị Bình Lưu, Khắc Tấn Nguyễn, Phú Hùng Nguyễn, Quốc Hoàn Phan

Ngôn ngữ: vie

Ký hiệu phân loại: 611.0187 Human anatomy, cytology, histology

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2022

Mô tả vật lý: 260-264

Bộ sưu tập: Metadata

ID: 499060

Thêm vào giỏ

Phân tích mối liên quan giữa kiểu hình miễn dịch CD44, ALDH với đặc điểm lâm sàng, nội soi và mô bệnh học trong ung thư biểu mô tuyến dạ dày. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang
thiết kế tiến cứu trên 121 bệnh nhân được chẩn đoán xác định ung thư biểu mô tuyến dạ dày và được phẫu thuật cắt bỏ khối u tại Bệnh viện K. Phân tích mối liên quan giữa CD44, ALDH và các thông số. Kết quả: Bệnh nhân có u thể loét có tỷ lệ biểu hiện CD44 cao hơn với 86,7%, p>
0,05. Bệnh nhân có u thể ruột có tỷ lệ biểu hiện CD44 cao hơn với 67,5%, p>
0,05. Bệnh nhân có u kích thước từ 2-<
5 cm có tỷ lệ biểu hiện ALDH cao nhất với 77,0%, p<
0,05. Bệnh nhân có u biệt hóa kém có tỷ lệ biểu hiện ALDH cao nhất với 58,1%, p<
0,05. Bệnh nhân có u giai đoạn III có tỷ lệ biểu hiện ALDH cao nhất với 71,6%, p<
0,05. Kết luận: Sự biểu hiện CD44 có xu hướng cao hơn ở thể loét và thể ruột. Sự biểu hiện ALDH có sự khác biệt theo kích thước khối u trên nội soi, độ biệt hóa và giai đoạn bệnh.To analyze the relationship between CD44 ALDH immunophenotype, with endoscopic and histopathological characteristics in gastric adenocarcinoma. Subject and Method: This was cross-sectional descriptive study
prospective design on 121 patients with confirmed diagnosis of gastric adenocarcinoma and surgical resection of the tumor at K Hospital. Analysis of the relationship between CD44, ALDH and parameters. Result: Patients with ulcerative tumors had a higher CD44 expression rate with 86.7%, p>
0.05. Patients with intestinal tumor had a higher CD44 expression rate with 67.5%, p>
0.05. Patients with tumor size from 2 to <
5 cm had the highest ALDH expression rate with 77.0%, p <
0.05. Patients with poorly differentiated tumors had the highest ALDH expression rate with 58.1%, p<
0.05. Patients with stage III tumor had the highest ALDH expression rate with 71.6%, p<
0.05. Conclusions: CD44 expression tends to be higher in ulcerative and intestinal forms. ALDH expression differs according to endoscopic tumor size, differentiation, and disease stage.

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