Đánh giá tính an toàn và mức độ phát triển sụn khớp của liệu pháp điều trị thoái hóa khớp gối bằng huyết tương giàu tiểu cầu kết hợp với tế bào gốc trung mô từ mô mỡ tự thân

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Tác giả: Trường Sinh Cao, Nhân Dương Đinh

Ngôn ngữ: vie

Ký hiệu phân loại: 611.0182 Human anatomy, cytology, histology

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2022

Mô tả vật lý: 172-176

Bộ sưu tập: Metadata

ID: 499069

Thêm vào giỏ

Đánh giá tính an toàn và mức độ phát triển sụn khớp trên cộng hưởng từ của liệu pháp điều trị thoái hóa khớp gối bằng huyết tương giàu tiểu cầu kết hợp với tế bào gốc trung mô từ mô mỡ tự thân. Đối tượng và phương pháp: 60 khớp gối trên 30 bệnh nhân, 26 nữ, 4 nam, tuổi trung bình 58,63 ± 11.11, được chẩn đoán thoái hóa theo Hội khớp học Hoa Kỳ (ACR) giai đoạn II - III theo Kellgren và Lawrence. Tất cả được tiêm hỗn hợp huyết tương giàu tiểu cầu tự thân tách chiết bằng bộ kít PRP, APC 30 PRP PRCEDURE PRAK và tế bào gốc trung từ mô mỡ bụng tự thân tách chiết bằng bộ kit ADI-25-01 ADIPOSEPRCEDURE PRAK với máy tách tế bào gốc Harvest của công ty TERUMO BCT- USA. Kết quả: Tỷ lệ khớp gối đau sau tiêm trên 3 giờ là 15/60 khớp (chiếm 25%). Trong đó 6 trường hợp đau kéo dài trên 24 giờ, 10% khớp gối tràn dịch sau tiêm. Không có BN biểu hiện nhiễm khuẩn khớp hay phần mềm quanh khớp sau tiêm. Có 73,3% bệnh nhân không đau kéo dài sau lấy mỡ bụng và không bị xuất huyết dưới da vùng bụng sau lấy mỡ. Sau 12 tháng điều trị: Có 52/60 (86.77%) khớp có thay đổi bề dày sụn và bề dày sụn khớp đùi chè tăng từ 1,56 ±0,25 mm trước điều trị lên đến 1,64±0,21mm. Kết luận: Liệu pháp điều trị thoái hóa khớp gối bằng huyết tương giàu tiểu cầu kết hợp với tế bào gốc trung mô từ mô mỡ tự thân là an toàn, tỷ lệ tai biến tại chỗ thấp và không có biến chứng nhiễm trùng cũng như tai biến toàn thân. Cải thiện bề dày sụn khớp bề dày sụn khớp trên cộng hưởng từ qua đó cải thiện chức năng vận động của khớp gối.The aim of this study is to evaluate the safety and cartilage growth levels on magnetic resonance of knee osteoarthritis therapy by platelet-rich plasma combined with mesenchymal stem cells from autologous adipose tissue. Objects and methods: 60 knee joints in 30 patients, 26 female, 4 male, mean age 58.63 ± 11.11 years, were diagnosed with degenerative disease according to American Society of Rheumatology (ACR) stage II - III according to Kellgren and Lawrence. All were injected with autologous platelet-rich plasma mixture extracted by PRP kit, APC 30 PRP PRCEDURE PRAK and autologous abdominal adipose stem cells were extracted by ADI-25-01 ADIPOSEPRCEDURE PRAK kit with machine Harvest stem cells from TERUMO BCT- USA. Result: The rate of knee pain after 3 hours of injection is 15/60 joints (25%). In which 6 cases of pain persisted for more than 24 hours, 10% of the knee joints effusion after injection. No patient showed infection of joints or soft tissues around the joints after injection. There were 73.3% patients with no persistent pain after fat removal and no bleeding under the skin of the abdomen after fat removal. After 12 months of treatment: 52/60 (86.77%) joints had a change in cartilage thickness and the cartilage thickness of the patellar joints increased from 1.56 ± 0.09 mm before treatment up to 1.65 ± 0.09 mm after treatment. Conclusion: The treatment of knee osteoarthritis with platelet-rich plasma combined with mesenchymal stem cells from autologous adipose tissue is safe, has a low rate of local complications, and has no infectious complications as well. whole body accident. Improve articular cartilage thickness articular cartilage thickness on magnetic resonance thereby improving the mobility function of the knee joint.

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