Đặc điểm huyết học và các thể bệnh hemoglobin của sinh viên năm nhất Trường Đại học Y dược Cần Thơ có hồng cầu nhỏ nhược sắc

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Tác giả: Hoàng Thi Lê, Thị Hoàng Mỹ Lê, Hồng Hà Nguyễn, Hữu Chường Nguyễn, Phúc Đức Nguyễn, Thị Ngọc Nga Phạm, Thanh Hải Phan

Ngôn ngữ: vie

Ký hiệu phân loại: 612.12 Blood chemistry

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2022

Mô tả vật lý: 226-230

Bộ sưu tập: Metadata

ID: 499285

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Chủ đề

Every year, students of Can Tho University of Medicine and Pharmacy (University of Medicine and Pharmacy) have a health check before admission and there are a large number of students (students) with hypochromic small red blood cells, a group of subjects at risk. Very high risk of carrying the hemoglobin disease gene. Objectives: To identify hemoglobin (Hb) disease forms and hematological characteristics of Hb disease forms in first-year students of the University of Traditional Chinese Medicine with hypochromic small red blood cells. Subjects and methods: A cross-sectional descriptive study on 219 hypochromic microcytic erythrocytes. Results: 39.7% of students had abnormalities in MCH (<
27pg) and 63.3% of students had abnormalities in both MCV (<
80fL) and MCH
There are 3 types of Hb disease, accounting for 32.9% total (72/219), heterozygous HbE (HbAE) accounted for 24.7%
Heterozygous β-Thalasemia (β-Thal) form accounted for 7.3% and HbH form of α-Thal disease (HbH) accounted for 0.9%. There are 58/72 (80.5%) Kinh people and 39/72 (54.2%) students are female
residence in Can Tho (15.3%) and other localities (84.7%). On hematological characteristics: red blood cell count
MCV
MCH, the average Hb index of β-Thal disease is: 6.06 ± 0.57x1012/L, respectively
70.43 ± 5.37fL
21.09 ± 2.06pg
12.81 ± 0.83g/dL
of HbAE disease are: 5.59± 0.55x1012/L, respectively
79.44 ± 3.42fL
25.2 ± 1.48pg
14.19 ± 0.52 g/dL and HbH form is: 7 ± 0.0x1012/L
66 ± 0.85fL
16.65±0.07pg
11 ± 0.0g/dL. Conclusions: The total prevalence of Hb among first-year students of the University of Traditional Chinese Medicine is 32.9%. There are 3 types of disease identified as: heterozygous HbE 24.7%
Heterozygous β-Thalaseemia was 7.3% and HbH form of α-Thal disease was lowest, 0.9%. Red blood cell count values
MCV
MCH, mean Hb index differs according to Hb disease types.Hàng năm sinh viên Trường Đại học Y Dược Cần Thơ (ĐHYDCT) được khám sức khoẻ trước khi nhập học và có số lượng không ít sinh viên (SV) có mang hồng cầu nhỏ nhược sắc, nhóm đối tượng có nguy cơ mang gen bệnh hemoglobin rất cao. Mục tiêu: Xác định các thể bệnh hemoglobin (Hb) và đặc điểm huyết học của các thể bệnh Hb ở SV năm nhất Trường ĐHYDCT có hồng cầu nhỏ nhược sắc. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang trên 219 SV hồng cầu nhỏ nhược sắc. Kết quả: Có 39,7% SV có bất thường MCH (<
27pg) và 63,3% SV có bất thường cả MCV (<
80fL) và MCH
Có 3 thể bệnh Hb chiếm tổng 32,9% (72/219), thể dị hợp tử HbE (HbAE) chiếm 24,7%
thể β-Thalasemia dị hợp tử (β-Thal) chiếm 7,3% và thể HbH của bệnh α-Thal (HbH) chiếm 0,9%. Có 58/72 (80,5%) thuộc dân tộc Kinh và 39/72 (54,2%) SV là nữ
nơi cư trú tại Cần Thơ (15,3%) và địa phương khác (84,7%). Về đặc điểm huyết học: số lượng hồng cầu
MCV
MCH, chỉ số Hb trung bình của thể bệnh β-Thal lần lượt là: 6,06 ± 0,57x1012/L
70,43 ± 5,37fL
21,09 ± 2,06pg
12,81 ± 0,83g/dL
của thể bệnh HbAE lần lượt là: 5,59± 0,55x1012/L
79,44 ± 3,42fL
25,2 ± 1,48pg
14,19 ± 0,52 g/dL và thể bệnh HbH là: 7 ± 0,0x1012/L
66 ± 0,85fL
16,65±0,07pg
11 ± 0,0g/dL. Kết luận: Tổng tỷ lệ mắc bệnh Hb ở sinh viên năm nhất Trường ĐHYDCT là 32,9%. Có 3 thể bệnh được xác định là: thể dị hợp tử HbE là 24,7%
thể β-Thalasemia dị hợp tử là 7,3% và thể HbH của bệnh α-Thal thấp nhất, 0,9%. Các giá trị số lượng hồng cầu
MCV
MCH, chỉ số Hb trung bình khác nhau theo các thể bệnh Hb.

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