Hiệu quả giảm cân và hạ lipid máu của hỗn hợp dịch chiết lá trà hoa vàng và giảo cổ lam trên chuột nhắt trắng gây béo phì

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Tác giả: Hồng Hạnh Nguyễn, Thanh Hà Tuấn Nguyễn, Thị Thanh Tú Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại: 613.25 Weight-losing diet

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2022

Mô tả vật lý: 164-172

Bộ sưu tập: Metadata

ID: 499866

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Nghiên cứu được thực hiện nhằm đánh giá tác dụng giảm cân, hạ lipid máu của hỗn hợp dịch chiết lá Trà hoa vàng và Giảo cổ lam trên chuột nhắt trắng gây béo phì. Chuột nhắt trắng chủng Swiss được chia ngẫu nhiên thành 5 lô với 8 con trong mỗi lô. Lô 1: chuột không gây béo phì. Với 4 lô còn lại, chuột được gây béo phì trong vòng 8 tuần. Sau đó với lô 2 chuột được uống nước cất, lô 3 chuột được uống hỗn hợp dịch chiết liều 12g/kg/ngày, lô 4 chuột được uống hỗn hợp dịch chiết liều 24g/kg/ngày và lô 5 chuột được uống atorvastatin liều 15mg/kg/ngày. Thời gian uống thuốc thử là 14 ngày. Trọng lượng chuột ở mỗi lô được đánh giá hàng tuần và hàm lượng Cholesterol toàn phần (CT), HDL-Cholesterol (HDL-C), LDL-Cholesterol (LDL-C) và Triglycerid (TC) tại các thời điểm chưa uống thuốc (sau gây béo phì 8 tuần) và sau uống thuốc thử ngày cuối 1 giờ. Kết quả cho thấy hỗn hợp dịch chiết lá Trà hoa vàng và Giảo cổ lam ở liều 12 g/kg/ngày và 24 g/ kg/ngày, atorvastatin liều 15 mg/kg/ngày (lô 3,4,5) đều giảm có ý nghĩa thống kê thể trọng chuột và các chỉ số CT, LDL-C và TC so với lô 2 (p <
0,05) và khác biệt không có ý nghĩa thống kê giữa các lô 3,4,5 (p >
0,05).The purpose of this study was to evaluate the effects of a mixture extract of C.chrysantha and G.pentaphyllum on weight loss and lowering lipid blood levels in obese Swiss mice. Swiss mice were randomly allocated into 5 groups with 8 animals in each group. Group 1: non-obese mice. With the remaining 4 groups, the mice were induced to become obese for 8 weeks. mice were fed with distilled water ( group 2) mixture extract at a dose of 12g/kg/day ( group 3), , 24g/kg/day ( group 4) and atorvastatin at a dose of 15mg/kg/day ( group 5). The feeding time period was 14 days. Mice in each group was assessed for weight weekly and the levels of Total Cholesterol (CT), HDLCholesterol (HDL-C), LDL-Cholesterol (LDL-C) and Triglyceride (TC) was recorded at initial time (after obesity was induced for 8 weeks) and 1 hour after taking the extracted mixtures on the last day. The results showed that the mixture extract of C.chrysantha and G.pentaphyllum at doses of 12 g/kg/day and 24 g/kg/day, atorvastatin at a dose of 15 mg/kg/day (group 3,4,5) induced weight loss and decreased TC, CT, LDL-C levels compared with group 2 (p <
0.05) and the difference was not statistically significant between groups 3,4,5 (p >
0.05).

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