Deletion of Pnpla2 Causes Malformation and Malperformance of Mouse Photoreceptors.

• Tác giả: Mones Abu-Asab, S Patricia Becerra, Alexandra Bernardo-Colón, Lijin Dong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 553.3 Iron
• Thông tin xuất bản: United States : Advances in experimental medicine and biology , 2025
• Bộ sưu tập: NCBI
• ID: 50046

Tóm tắt

Photoreceptor cells express the patatin-like phospholipase domain-containing 2 (PNPLA2) gene that codes for pigment epithelium-derived factor receptor (PEDF-R). PEDF-R exhibits phospholipase activity that mediates the neurotrophic action of its ligand PEDF. Because phospholipids are the most abundant lipid class in the retina, we investigated the role of PNPLA2 in photoreceptors by generating CRISPR Pnpla2 knockout mouse lines. We aim to characterize one of the two lines of mice generated with global Pnpla2 gene deletion. The retinas of Pnpla2