Thyroid hormone (TH) signaling is essential for cell proliferation, differentiation, and metabolic homeostasis. In the retina, TH signaling regulates retinal development, cone opsin expression, and photoreceptor viability. Suppressing TH signaling protects photoreceptors in mouse models of retinal degeneration whereas excessive TH signaling induces photoreceptor degeneration in mice. This work examined stress responses in the mouse retina after stimulation of TH signaling. C57BL/6 and Nrl