From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Ashraf H Abadi, Mohammad Abdel-Halim, Sarah S Darwish, Matthias Engel, Donia E Hafez, Mostafa M Hamed, Anna K H Hirsch, Jim-Tong Horng, Andreas M Kany, Parthiena M Keddis, Tuong-Khanh My Tu, Hugo Scherer

Ngôn ngữ: eng

Ký hiệu phân loại: 362.8294 Problems of and services to other groups

Thông tin xuất bản: France : European journal of medicinal chemistry , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 500610

Enterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth disease (HFMD) especially in children. The majority of EV-A71 cases are mild, however, severe cases have exhibited an array of neurological complications which often lead to death. In a screening campaign to discover hits against EV-A71, we identified six 2,4-diaryl-substituted thiophene compounds that were previously reported as Dyrk1A inhibitors. From these, compound S43 (EC
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH