Đánh giá kết quả điều trị tấn công bệnh đa u tủy xương bằng phác đồ có Bortezomib tại Bệnh viện Đà Nẵng

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Thị Ngọc Vân Huỳnh, Hoàng Trường Lê, Phạm Thanh Nhân Nguyễn, Thị Hoàng Yến Nguyễn, Thị Thanh Hương Trần, Thế Diễm Trinh Trương

Ngôn ngữ: vie

Ký hiệu phân loại: 378.597 Higher education

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2022

Mô tả vật lý: 348-353

Bộ sưu tập: Metadata

ID: 500736

Thêm vào giỏ

Đánh giá kết quả điều trị tấn công bệnh đa u tủy xương bằng phác đồ có bortezomib và tác dụng không mong muốn tại Bệnh viện Đà Nẵng. Đối tượng và phương pháp: Thực hiện nghiên cứu hồi cứu mô tả cắt ngang trên 50 bệnh nhân đa u tủy xương được dùng phác đồ có bortezomib điều trị tại Bệnh viện Đà Nẵng từ tháng 4/2017 đến tháng 8/2020. Kết quả - Kết luận: 50 bệnh nhân đa u tủy được phân tích. Tuổi trung vị là 65 tuổi. Nam giới chiếm 40%. Sau 4 đợt điều trị, ghi nhận 54% bệnh nhân đạt đáp ứng hoàn toàn, 12% đạt đáp ứng một phần rất tốt, 14% đạt đáp ứng một phần, 20% bệnh không đổi hoặc tiến triển. Tỉ lệ đáp ứng chung sau 4 đợt điều trị theo các phác đồ VCD là 21 trên tổng số 23 ca, VTD là 7 trên tổng số 13 ca, VD là 11 trên tổng số 12 ca, RVD là 1 trên tổng số 2 ca. Độc tính ghi nhận là có thể chấp nhận được.Evaluating the outcome of induction therapy for multiple myeloma with regimens containing bortezomib and adverse effects at Danang Hospital. Materials and methods: Conducted a retrospective descriptive cross-sectional study on 50 patients with multiple myeloma who received bortezomib-containing regimens at Danang Hospital from April 2017 to August 2020. Results and Conclusions: The results have been investigated on 50 multiple myeloma patients. The median age was 65 years old. Men was 40%. After 4 courses of treatment, 54% of patients achieved a complete response, 12% achieved a very good partial response, 14% achieved a partial response, and 20% of the patients remained unchanged or progressed. The overall response rate after 4 courses of VCD regimens was 21 out of 23 patients, VTD was 7 out of 13 patients, VD was 11 out of 12 patients and RVD was 1 out of 2 patients. Toxicity noted was acceptable.

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