Vai trò tiềm năng giá trị Q của tế bào lympho kích thích trên máy huyết học tự động Sysmex trong chẩn đoán phân biệt Covid-19 với nhiễm các virus khác

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Tác giả: Trung Kiên Nguyễn, Việt Hưng Tạ, Hồng Anh Vũ

Ngôn ngữ: vie

Ký hiệu phân loại: 362.1962414 Physical illness

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2022

Mô tả vật lý: 527-533

Bộ sưu tập: Metadata

ID: 500744

Thêm vào giỏ

Khảo sát giá trị Q của tế bào lympho kích thích (QAL) trên máy huyết học tự động Sysmex trong việc chẩn đoán phân biệt nhiễm COVID-19 với nhiễm các virus khác. Đối tượng và phương pháp: nghiên cứu mô tả cắt ngang, hồi cứu trên hai nhóm bệnh nhân gồm 149 bệnh nhân nhiễm COVID-19 (nhóm COV19+) và 67 bệnh nhân nhiễm các virus khác (nhóm COV19-). Nghiên cứu được thực hiện tại Bệnh viện Quân y 103 từ tháng 6/2021 đến tháng 2/2022. Kết quả: Tuổi trung bình của bệnh nhân là 47,6 ± 21,9 (từ 18 đến 97 tuổi). Có 117 trường hợp (54.2%) là nam giới và 99 trường hợp (45.8%) là nữ giới. Về lâm sàng, lúc nhập viện, ho là triệu chứng nổi bật của nhóm COV19+, trong khi đó sốt và đau đầu chiếm ưu thế ở nhóm COV19-. Kết quả của nghiên cứu cho thấy giá trị QAL thấp hơn có ý nghĩa ở nhóm COV19+ so với nhóm COV19- (p<
0.001). Các phân tích của chúng tôi chỉ ra rằng sử dụng giá trị ngưỡng ở 90 của QAL đạt hiệu quả cao trong việc chẩn đoán phân biệt sớm nhóm COV19+ với nhóm COV19- , với độ nhạy và độ đặc hiệu lần lượt là 87.92% và 86.57%. Kết luận: Kết quả của nghiên cứu này cho thấy sự hữu ích và tiềm năng của giá trị QAL trong việc chẩn đoán phân biệt sớm COVID- 19 với các bệnh lý nhiễm virus khác.We assessed the diagnostic value of the Q-value of reactive lymphocytes (QAL) from Sysmex hematology analyzer in differentiating patients with COVID-19 and other viral infections. Subjects and methods: A descriptive cross-sectional study on 149 patients with COVID-19 (COV19+) and 67 patients with other viral infections (COV19-). The study was conducted at 103 Military Hospital between June 2021 and February 2022. Results: The average age of the patiens was 47.6 ± 21.9 (range 18 to 97). There were 117 male patients (54.2 %) and 99 female patients (45.8%). At the time of admission, cough was the most common symptom in the COV19+ group, while fever and headache were the most common symptoms in the COV19- group. Our findings revealed that the QAL was significantly lower in the COV19+ group than the COV19- group (p<
0.001). The main analysis of this study found that the QAL parameter with a cutoff value of 90 demonstrates a good diagnostic value for differentiating COVID-19 from other viral infections at an early stage (sensitivity and specificity of 87.92% and 86.57 %, respectively). Our findings suggest that the Q-value may have a potential value in early differentiating COVID-19 from other viral infection.

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