Báo cáo ca bệnh lơ xê mi cấp tiền tủy bào hiếm gặp tại Viện Huyết học và Truyền máu Trung ương

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Thị Thủy Cao, Ngọc Dũng Nguyễn, Thị Mai Nguyễn, Thị Xuân Nguyễn, Vũ Thịnh Nguyễn, Hải Yến Phạm, Thị Nguyệt Anh Phí

Ngôn ngữ: vie

Ký hiệu phân loại: 612.11822 Blood and circulation

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2022

Mô tả vật lý: 374-379

Bộ sưu tập: Metadata

ID: 500806

Thêm vào giỏ

Acute promyelocytic leukemia is a rare form of malignant blood cancer. Common symptoms of the disease are anemia, coagulative disorders and infections. However, extramedullary manifestation of tumor cells as spinal, skin or nerve in acute promyelocytic leukemia is a very rare condition. We record and report a case of a 22-year-old male patient who was admitted to the hospital because of bone paiting, weakness of the four limbs with ascending level beside anemia and coagulated disorder. He was diagnosed acute promyelocytic leukemia with nerve involvement based on bone marrow aspiration, bone marrow biopsy, PML/RARa gene mutation, t(15
17) mutation on FISH and MRI. He recieved Daunorubicin + ATRA and initially showed great clinical improvement.Lơ xê mi cấp tiền tủy bào là một thể ung thư máu ác tính với triệu chứng chủ yếu là thiếu máu, rối loạn đông máu và nhiễm khuẩn. Thâm nhiễm ngoài tủy như da, thần kinh TW, lợi rất hiếm gặp ở bệnh nhân mới được chẩn đoán, mặc dù những biểu hiện này cũng đã được mô tả với tỷ lệ thấp trong những trường hợp tái phát. Chúng tôi ghi nhận và báo cáo một trường hợp bệnh nhân nam 22 tuổi, nhập viện vì đau xương, yếu các chi tăng dần kèm theo thiếu máu nhẹ và rối loạn đông máu. Bệnh nhân được chẩn đoán lơ-xê-mi cấp tiền tủy bào có thâm nhiễm thần kinh dựa trên sinh thiết tủy xương, gene PML/RARa và FISH t(15
17) dương tính và kết quả chụp MRI. Bệnh nhân được điều trị theo phác đồ với Daunorubicin + ATRA và cho thấy sự cải thiện rõ rệt về lâm sàng.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR