Tác dụng hạ glucose máu của hỗn hợp dịch chiết trà hoa vàng, giảo cổ lam, dây thìa canh lá to, xạ đen trên chuột nhắt trắng gây đái tháo đường type 2

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Tác giả: Hoàng Ngân Nguyễn, Hồng Hạnh Nguyễn, Thị Thanh Tú Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại: 616.462 Diabetes mellitus

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2022

Mô tả vật lý: 259-267

Bộ sưu tập: Metadata

ID: 500825

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Chủ đề

Nghiên cứu được thực hiện nhằm đánh giá tác dụng hạ glucose máu của hỗn hợp dịch chiết lá Trà hoa vàng, Giảo cổ lam, Dây thìa canh lá to và Xạ đen trên chuột nhắt trắng gây đái tháo đường type 2 bằng nicotinamide (NA) và streptozotocin (STZ). Chuột nhắt trắng chủng Swiss được chia thành 5 lô, mỗi lô 10 con. Lô 1 (không gây đái tháo đường), lô 2, 3, 4, 5 (gây đái tháo đường type 2 bằng cách tiêm màng bụng NA và STZ theo quy trình nghiên cứu). Lô 1 và lô 2 (uống nước cất)
lô 3 (uống Metformin liều 200 mg/kg/ngày)
lô 4 và lô 5 (uống dịch chiết liều 24 g/kg/ngày và 48 g/kg/ngày), thời gian uống nước cất hoặc thuốc thử 14 ngày. So sánh giữa các lô về nồng độ glucose máu, insulin máu và các chỉ số đánh giá sự kháng insulin. Kết quả cho thấy, hỗn hợp dịch chiết ở cả hai liều có tác dụng hạ glucose máu, giảm chỉ số HOMA-IR, tăng các chỉ số HOMA-β, chỉ số QUICKI, chỉ số DI và tăng phần trăm khối lượng tụy so với khối lượng cơ thể (so với lô 2, p <
0,05) và tương đương với lô 3 (p >
0,05).The purpose of this study was to evaluate the hypoglycemic effect of a mixture extraction of C.chrysantha, G.pentaphyllum, G.latifolium and C.hindsii on streptozotocin - nicotinamide - induced type 2 diabetes mice. Swiss white mice were randomly allocated into 5 groups, 10 mice per group. Group 1: non-induced diabetes mice. Group 2, 3, 4, 5: diabetes was induced in mice by intraperitoneal injection of nicotinamide (NA) and streptozotocin (STZ). Mice in group 1 and group 2 were administered distilled water
in group 3, administered Metformin at a dose of 200 g/kg b.w./day
in group 4 and group 5, administered the mixture extraction at a dose of 24 g/kg b.w./day and 48 g/kg b.w./day, respectively. The total period of distilled water or reagent administration was 14 days. Data of serum glucose levels, serum insulin levels and insulin resistance indices were compared between groups. The results showed that the mixture extraction at both two doses significantly reduced the serum glucose levels, the HOMA-IR index and significantly increased the HOMA-β index, QUICKI index, DI index and the percentage of pancreas out of total body weight (compared to group 2, p <
0.05) and equivalent to group 3 (p >
0.05).

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