Laser technology has affected the field of Periodontology in many ways. They help to manage periodontal disease. This investigation aimed to compare the clinical results of diode laser in conjunction with scaling and root planing (SRP) and SRP alone in treating periodontal pockets in Periodontitis patients. This randomized controlled clinical research utilized a split-mouth approach. It included 25 patients (11 females and 14 males, aged 20 to 65) presenting a moderate periodontal pocket with depths of 4-7 mm on both the right and left sides of the mouth. Two groups were utilized: the control group (SRP alone) on the right side of the mouth and the experimental group (SRP in conjunction with diode laser) on the left side of the mouth. The intervention comprised a single session of scaling and root planing (SRP) accompanied by 10-second administrations of a dual-wavelength diode laser Working within the wavelength range 810-980 nm on the left side. In contrast, the contralateral side received SRP only. Probing Pocket Depth, clinical attachment loss, Plaque Index, and Bleeding on Probing Index were assessed at baseline, 1.5 months, and 3 months post-treatment. The results indicate that both therapies enhanced periodontal parameters at 1.5 and 3 months compared to the baseline. SRP + diode laser, on the other hand, demonstrated a substantial enhancement in probing depth.(PD
4.92 ± 0.65-3.82 ± 0.87-3.55 ± 0.80 vs. 4.95 ± 0.67-4.14 ± 0.93-3.90 ± 0.93, p <
0.001) and BOP%(100.0%-43.2%-34.80% vs. 100.0%-54.8%-44.0%, P <
0.05) in contrast to SRP alone. No substantial differences were detected in CAL and plaque percentages between treatment groups (P >
0.05) at 1.5 and 3 months post-treatment. Conclusions indicate that within the limit of this study, the integration of scaling and root planing (SRP) with diode laser therapy resulted in a significant reduction in moderate periodontal pocket depth and bleeding on probing over the 3-month trial period in patients with Periodontitis.