Tỷ lệ chu kỳ chuyển phôi trữ lạnh có nồng độ progesterone huyết thanh thấp và các yếu tố liên quan tại Bệnh viện Hùng Vương

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Tác giả: Phúc Khánh Minh Huỳnh, Thị Vân Trâm Lê, Thái Lộc Lý, Ánh Ngọc Nguyễn, Thị Ngọc Lan Vương

Ngôn ngữ: vie

Ký hiệu phân loại: 612.64 Physiology of embryo and fetus

Thông tin xuất bản: Tạp chí Phụ sản, 2023

Mô tả vật lý: 74-79

Bộ sưu tập: Metadata

ID: 502280

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Investigating the prevalence and and associated factors of frozen-thawed cycles with low serum progesterone concentration (<
10 ng/mL) on the day of embryo transfer. Materials and methods: A cross-sectional study was conducted on 367 frozen-thawed cycles with artificial endometrium preparation at Hung Vuong Hospital from October 2022 to February 2023. Results: The prevalence of frozen-thawed cycles with low serum progesterone concentration (<
10 ng/mL) on the day of embryo transfer was 71.66%. Factors associated with low serum progesterone concentration were higher female body weight (OR = 1.04
95% CI: 1.0006 - 1.07, p = 0.05) and increased duration from the last dose of progesterone to the time of blood sampling (OR = 1.11
95% CI: 1.03 - 1.19, p = 0.004). Conclusions: High prevalence of frozen-thawed cycles with low serum progesterone concentration was identified. Factors associated with low serum progesterone concentration were higher female body weight and increased duration from the last dose of progesterone to the time of blood sampling.Xác định tỷ lệ chu kỳ chuyển phôi trữ lạnh có nồng độ progesterone huyết thanh thấp (<
10 ng/mL) vào ngày chuyển phôi và khảo sát các yếu tố có liên quan đến nồng độ progesterone huyết thanh thấp. Đối tượng và phương pháp nghiên cứu: Nghiên cứu cắt ngang mô tả được thực hiện tại Bệnh viện Hùng Vương từ tháng 10/2022 - 02/2023 trên 367 chu kỳ chuyển phôi trữ lạnh được chuẩn bị nội mạc tử cung bằng phác đồ chu kỳ nhân tạo. Kết quả: Tỷ lệ chu kỳ chuyển phôi trữ lạnh có nồng độ progesterone huyết thanh thấp vào ngày chuyển phôi là 71,66%. Phân tích hồi quy logistic đa biến cho thấy cân nặng tăng làm tăng nguy cơ nồng độ progesterone huyết thanh thấp ở ngày chuyển phôi lên 1,04 lần (OR
KTC 95%: 1,0006 - 1,07, p = 0,05) và thời gian từ khi dùng liều progesterone cuối đến thời điểm lấy máu càng dài thì nguy cơ nồng độ progesterone thấp tăng 1,11 lần (OR
KTC 95%: 1,03 - 1,19, p = 0,004). Kết luận: Tỷ lệ chu kỳ chuyển phôi trữ lạnh có nồng độ progesterone huyết thanh thấp vào ngày chuyển phôi là cao. Yếu tố liên quan của nồng độ progesterone thấp vào ngày chuyển phôi là cân nặng tăng và thời gian từ liều progesterone cuối đến khi lấy máu xét nghiệm kéo dài.

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