Tác dụng không mong muốn của phác đồ xelox hóa trị bổ trợ cho bệnh ung thư biểu mô dạ dày giai đoạn II-IIIC

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Tác giả: Anh Tú Đỗ, Thammavong Phonesavanh

Ngôn ngữ: vie

Ký hiệu phân loại: 616.33 *Diseases of stomach

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2023

Mô tả vật lý: 148-152

Bộ sưu tập: Metadata

ID: 502497

Thêm vào giỏ

In gastric cancer, the XELOX chemotherapy regimen combines Oxaliplatin and Capecitabine, with high treatment efficiency, few side effects, and improved overall survival and disease-free survival. Purpose: To assess the side effects of XELOX regimen in stomach cancer stage II - IIIC at K Hospital. Methods: the side effects were recorded in 109 gastric cancer patients receiving adjuvant treatment with Xelox regimen. Results: The side effects are, mostly grade 1, 2. Decrease of hemoglobin is the most common, accounting for 49.7%. The rate of leukopenia, granulocytosis, and thrombocytopenia were accounted in 11.6%, 28%, 26.4%, respectively. Elevated hepatic enzymes as SGOT and SGPT were found in 1.72% and 1.3%, respectively. Conclusion: Adjuvant chemotherapy with XELOX is a safe regimen, with few side effects, mostly in grade 1, 2.Trong ung thư dạ dày phác đồ hóa trị XELOX kết hợp giữa hai loại hóa chất là Oxaliplatin và Capecitabin cho hiệu quả điều trị cao, ít tác dụng phụ, cải thiệt thời gian sống thêm không bệnh về toàn bộ. Mục tiêu: Nhận xét một số tác dụng không mong muốn của phác đồ XELOX ở bệnh ung thư dạ dày giai đoạn II - IIIC tại Bệnh viện K. Đối tượng và phương pháp nghiên cứu: Ghi nhận các tác dụng không mong muốn của 109 bệnh nhân ung thư dạ dày được điều trị bổ trợ phác đồ Xelox. Kết quả nghiên cứu: Tác dụng không mong muốn, hầu hết ở độ 1, 2. Giảm huyết sắc tố gặp nhiều nhất, chiếm 49,7%. Tỉ lệ giảm bạch cầu, bạch cầu hạt, tiểu cầu lần lượt là: 11,6%
28%
26,4%. Tăng men gan SGOT, SGPT gặp ở 1,72% và 1,3%. Kết luận: Phác đồ XELOX là một phác đồ an toàn, ít tác dụng không mong muốn, hầu hết ở độ 1, 2.

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