Biểu hiện hóa mô miễn dịch của Ki67 trong ung thư biểu mô tuyến ống của tụy

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Tác giả: Thị Bích Nhàn Hoàng, Văn Thịnh Hoàng, Thị Tuyết Hạnh Ngô, Bùi Ngọc Diệp Nguyễn, Quang Thông Phạm, Thị Thanh Trâm Trần

Ngôn ngữ: vie

Ký hiệu phân loại: 616.37 *Diseases of pancreas

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2023

Mô tả vật lý: 372-376

Bộ sưu tập: Metadata

ID: 502509

Thêm vào giỏ

Khảo sát biểu hiện hóa mô miễn dịch của dấu ấn Ki67 trên bệnh nhân ung thư biểu mô tuyến ống của tụy và phân tích thời gian sống theo chỉ số Ki67 trên bệnh nhân ung thư biểu mô tuyến ống của tụy. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả hàng loạt ca trên 102 trường hợp ung thư biểu mô tuyến ống của tụy được phẫu thuật tại Bệnh viện Chợ Rẫy trong khoảng thời gian từ tháng 3/2017 đến tháng 12/2022. Kết quả: Chỉ số Ki67 trung bình là 17,2±1,4%. Chỉ số Ki67 ở nhóm có hoại tử u và không có hoại tử u lần lượt 20,5% và 13,3%
sự khác biệt có ý nghĩa thống kê (p=0,006). Chỉ số Ki67 ở độ biệt hóa rõ, vừa và kém lần lượt là 10,7%, 17,0% và 19,7%
sự khác biệt có ý nghĩa thống kê (p=0,022). Chỉ số Ki67 ở độ mô học 1, 2 và 3 lần lượt là 6,3%, 17,4% và 19,3%
sự khác biệt có ý nghĩa thống kê (p=0,002). Thời gian sống trung bình ở nhóm có chỉ số Ki67 <
10% và ≥10% lần lượt là 24,7 tháng và 23,5 tháng
sự khác biệt chưa có ý nghĩa thống kê (p=0,614). Kết luận: Những bệnh nhân có đặc điểm hoại tử u, độ biệt hóa vừa và kém, và độ mô học 2 và 3 có tỉ lệ bắt màu Ki67 cao hơn đáng kể so với những bệnh nhân không hoại tử u, độ biệt hóa rõ và độ mô học 1. Chỉ số Ki67 chưa cho thấy đây là một yếu tố ảnh hưởng đến thời gian sống của bệnh nhân ung thư biểu mô tuyến ống của tụy.To describe the immunohistochemical expression of Ki67 in pancreatic ductal adenocarcinoma and to analyze the survival time according to the Ki67 index in patients with pancreatic ductal adenocarcinoma. Material and method: Case series of 102 cases of pancreatic ductal adenocarcinoma operated at Cho Ray Hospital between March 2017 and December 2022. Results: The mean of the Ki67 index is 17.2±1.4%. The Ki67 index in the group with and without tumor necrosis was 20.5% and 13.3%, respectively
the difference is statistically significant (p=0.006). The Ki67 index at well, moderately, and poorly differentiated grades is 10.7%, 17.0%, and 19.7%, respectively
the difference is statistically significant (p=0.022). The Ki67 index at histological grades 1, 2, and 3 are 6.3%, 17.4%, and 19.3%, respectively
the difference is statistically significant (p=0.002). The mean survival time in the group with Ki67 index <
10% and ≥10% was 24.7 months and 23.5 months, respectively
the difference is not statistically significant (p=0.614). Conclusion: Patients with tumor necrosis, moderately and poorly differentiated, and histological grades 2 and 3 had percentages of Ki67 stained cells higher than patients without tumor necrosis, well differentiated, and histological grade 1, significantly. The Ki67 index has not been shown to be a factor affecting the survival time of patients with pancreatic ductal adenocarcinoma.

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