Tác dụng làm lành vết thương và tính kích ứng da của cao chiết và chế phẩm kem chứa cao chiết lá Chùm ngây trên thực nghiệm

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Tác giả: Trường Sơn Đinh, Bích Thảo Lâm, Quí Trí Lê, Thị Kim Oanh Lê, Văn Minh Lê, Hải Triều Lý, Thị Thu Hương Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại: 617.2 Results of injuries and wounds

Thông tin xuất bản: Khoa học (Đại học Quốc tế Hồng Bàng), 2023

Mô tả vật lý: 27-34

Bộ sưu tập: Metadata

ID: 502536

Thêm vào giỏ

Các sản phẩm từ thảo dược được sử dụng phổ biến để chữa lành vết thương. Lá Chùm ngây (Moringa oleifera Lam.) được biết có khả năng làm lành vết thương. Mục tiêu: Khảo sát tác dụng làm lành vết thương và tính kích ứng da của cao chiết và chế phẩm dạng kem có chứa cao lá Chùm ngây. Đối tượng và phương pháp: Mô hình chuột cắt da gây vết thương hở được áp dụng để khảo sát tác dụng làm lành vết thương của cao chiết và chế phẩm. Tính kích ứng da của cao chiết và chế phẩm được đánh giá bằng thử nghiệm kích ứng da thỏ. Kết quả: Cao lá Chùm ngây nồng độ 7.5% w/v có tác dụng làm lành vết thương tốt hơn các nồng độ khác thông qua khả năng làm giảm diện tích vết thương. Điều trị vết thương với chế phẩm kem có chứa 7.5% w/v cao lá Chùm ngây đã làm tăng đáng kể sự co vết thương sau 3 ngày điều trị. Hơn nữa, cao chiết nồng độ 7.5% và chế phẩm kem có khả năng tái tạo cấu trúc mô da tại vùng vết thương sau 11 ngày điều trị. Mặt khác, cao chiết và chế phẩm gây kích ứng không đáng kể trên da thỏ. Kết luận: Cao chiết và chế phẩm kem chứa cao lá Chùm ngây ở nồng độ 7.5% có tác dụng làm lành vết thương chuột và an toàn trên da thỏ.Herbal products have been commonly used to heal wounds. Moringa leaves (Moringa oleifera Lam.) are known to have wound healing capacity. Ojective: Investigating the wound healing activity and dermal irritation of extract and cream preparation containing Moringa leaf extract. Methods: Excision wound model in mice was applied to investigate the wound healing activity of the extract and preparation. Skin irritation of the extract and preparation was evaluated by rabbit skin irritation test. Results: Moringa leaf extract at concentration of 7.5% w/v had a better wound healing effect than other concentrations through its ability to reduce wound area. Treatment of wounds with cream containing 7.5% w/v Moringa leaf extract significantly increased wound contraction after 3 days. Furthermore, the extract and cream preparation had the ability to regenerate skin tissue structure in the wound area after 11 days of treatment. On the other hand, the extract and preparation were not significantly irritating to rabbit skin. Conclusions: The extract and cream preparation of Moringa leaves at concentration of 7.5% w/v had wound healing effect in mice and had no irritation on rabbit skin.

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