Separation and Quantitative Estimation of Pharmacopeial Organic Impurities, Process-Related Impurities, and Degradation Products of the Anti-Schizophrenia Drug Clozapine in Pharmaceutical Formulations by Using Stability-Indicating HPLC Method.

• Tác giả: Narasimha Swamy Lakka, Bhujanga Rao Nagulancha, Narayana Reddy Pedavenkatagari, Abhishek Sharma
• Ngôn ngữ: eng
• Ký hiệu phân loại: 621.374 Instruments for measuring specific electrical quantities
• Thông tin xuất bản: England : Biomedical chromatography : BMC , 2025
• Bộ sưu tập: NCBI
• ID: 50268

Tóm tắt

Clozapine is an antipsychotic medication primarily used to treat severe schizophrenia symptoms. This research aimed to develop and validate a reliable, rapid, and sensitive reverse-phase high-performance liquid chromatography (RP-HPLC) method for measuring organic impurities in clozapine drug substances and products. The chromatographic separation was achieved using an Agilent Poroshell 120 EC-C