Genetic variation in melanocortin-1 recepter (MC1R) gene, partial coding sequences (460bp), of the Edible-nest swiftlet (Aerodramus fuciphagus) from Sinh Oinh province was analyzed based on bioinformatic tools. The MC1 R gene was known that regulate the synthesis of melanine pigment color of bird feathers. The results indicate that there are two nucleotide polymorphism sites, but both two nucleotide substitutions are synonym.