Based on analysis of previous scientific data and study results of the survey in Xuan Thuy National Park (XTNP) in December, 2012, the status on biodiversity of XTNP is presented at levels of ecosystens and species composition. XTNP has many types of ecosystems with different characteristics on natural conditions, habitats and biomes. Up to now, 1,514 species are recorded in XTNP, belonging to groups of plants, plankton, sea-weed and sea-grass, macroinvertebrates, fishes, insects, reptile-amphibians, birds and mammania. Xuan Thuy National Park is under a number of pressures, especially anthropogenic activities in process of socio-economic development. Those pressures cause degradation of natural resources and biodiversity, and thereby leading to conflicts between different interest groups. Some measures for effected conservation and sustainable use of resources in wetland of XTNP that are given in this paper.