Cross-sectional study of 76 patients, to identify the role of NT-proBNP testing in heart failure diagnosis and to determine the association between NT-proBNP and grading of heart failure in patients with chronic renal failure, who were having periodic dialysis. The results showed that, the best cut point of the concentration of NT- proBNP which has diagnostic value for heart failure in patients with chronic renal failure, who were having periodic dialysis is 1802 pg/ml (NT-proBNP testing had a sensitivity of 88.64 percent and a specificity of 84.37 percent, area under the curve AUC is 0.945). NT-proBNP concentration increases with the level of heart failure: Level I (2708.25 + or - 1314.36 pg/ml), level II (8098.77 + or - 4523.40 pg/ml), level III (14748.50 + or - 9012.24 pg/ml) and level IV (30843.50 + or - 9902.04 pg/ml). There are,~ very tight positive correlation between the concentration of NT - proBNP and the level of heart failure (r = 0.818).